Zyprexa (Olanzapine) Withdrawal

Zyprexa withdrawal timeline at a glance

When did you last use or take it?

⚠ Medical warning (read before using this)

Don’t stop this medicine suddenly or change your dose without talking to your prescriber. The main risk of stopping is the condition it treats coming back, sometimes quickly. If you have thoughts of suicide, call or text 988 now.

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This places the typical ranges from this article's sources on your date. It is not a prediction or a diagnosis, and being past a phase does not mean symptoms or risks are over.

A rough guide from published sources, not medical advice. Everyone is different.

Phase	When	What you may feel	Severity	Red flags
Early withdrawal	The first days after a sudden stop (timing not well studied)	Feeling or being sick; Sweating; Difficulty sleeping	Moderate	—
Following weeks	Weeks to months	Return of the condition it treats	Moderate	Return of mania, psychosis or severe depression; Thoughts of suicide or self-harm: call or text 988 now

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Symptoms, phase by phase

The NHS lists feeling or being sick, sweating and difficulty sleeping as possible withdrawal symptoms, and says gradual reduction helps prevent them. It also warns that symptoms of your condition may come back if you stop suddenly. We didn’t find a detailed timeline in the FDA label.

Early withdrawal: The first days after a sudden stop (timing not well studied)

• Feeling or being sick
• Sweating
• Difficulty sleeping

Following weeks: Weeks to months

• Return of the condition it treats

What makes withdrawal longer or shorter

• Speed of stopping. The NHS says reducing the dose gradually helps prevent withdrawal symptoms.
• Why you take it. Relapse is the main concern in bipolar disorder and schizophrenia.

When to see a doctor or get help now

• Before stopping.
• Call or text 988 for thoughts of suicide.
• Signs of your condition returning: contact your care team.

Not sure where to start? Call SAMHSA’s free, confidential helpline at 1-800-662-4357, 24/7. See Get Help.

Tapering

The NHS says your doctor will help you come off it by reducing the dose gradually. We don’t publish dose-by-dose schedules. Your prescriber should set your plan, and adjust it if symptoms appear.

Tips for getting through it

• Agree on relapse warning signs
• Wake up and get out of bed at the same time every day (NHS)
• Keep a mood and sleep diary

Frequently asked questions

What are olanzapine withdrawal symptoms?

The NHS lists feeling or being sick, sweating and trouble sleeping.

Is Zyprexa addictive?

The NHS says no.

Will I lose the weight I gained?

The NHS says olanzapine can make you hungrier and put on weight. Talk to your doctor if you’re worried about your weight; don’t stop just for weight without a plan.

Next steps

• Track your dayEnter when you stopped to see where you are on the timeline
• Combine timelinesAdd other things you are stopping and see them on one chart
• Talk to othersAsk questions on our community forum (peer support, not medical advice)
• Read nextSeroquel (Quetiapine) Withdrawal Timeline
• Get helpFree, confidential helplines and when to see a doctor

Related timelines

• Seroquel (Quetiapine) Withdrawal Timeline
• Abilify (Aripiprazole) Withdrawal
• Lithium: What Happens When You Stop

Sources

1. NHS: Olanzapine
2. FDA label: Zyprexa (olanzapine) (DailyMed)
3. NHS: Insomnia

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Last reviewed: October 25, 2026. Researched and written by Withdrawal Timelines from the cited sources. This article has not yet been reviewed by a medical professional. See How We Review and our Medical Disclaimer. This is general information, not medical advice.