Trintellix (Vortioxetine) Withdrawal

Published by Joseph, EditorCompiled from cited sources · not yet medically reviewedUpdated Oct 26, 20263 sources

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For information only, not medical advice. Talk to a doctor before stopping or changing any medication. Medical disclaimer

⚠ Medical warning

Don’t stop your antidepressant suddenly or change your dose without talking to your prescriber. A gradual taper lowers the risk of withdrawal symptoms. If you have thoughts of suicide, call or text 988 now.

Quick answer

Vortioxetine (Trintellix) has a long half-life of about 66 hours. Its FDA label says it can be discontinued abruptly, but that in trials people stopping 15 or 20 mg a day had temporary headache and muscle tension, and it still recommends a gradual reduction whenever possible. RCPsych lists vortioxetine among antidepressants with a low potential risk of withdrawal symptoms.

Trintellix withdrawal timeline at a glance

When did you last use or take it?

⚠ Medical warning (read before using this)

This places the typical ranges from this article's sources on your date. It is not a prediction or a diagnosis, and being past a phase does not mean symptoms or risks are over.

A rough guide from published sources, not medical advice. Everyone is different.

Phase	When	What you may feel	Severity	Red flags
Onset	Within 1 to 2 days of a reduction, stop or missed dose; building over a few days	Headache; Muscle tension; Dizziness; Irritability	Moderate	Thoughts of suicide or self-harm: call or text 988 now
Acute withdrawal	First 1 to 2 weeks for many people	Dizziness, ‘brain zaps’ (electric shock sensations); Anxiety, irritability, mood swings; Vivid dreams, poor sleep; Flu-like feelings, nausea; Headache	Moderate	Thoughts of suicide or self-harm: call or text 988 now; Severe agitation, confusion, or feeling unable to stay still (akathisia)
Longer withdrawal (some people)	Weeks to months, occasionally more than a year	Mood and anxiety symptoms; Dizziness, sensory symptoms; Sleep problems	Moderate	Thoughts of suicide or self-harm: call or text 988 now

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Symptoms, phase by phase

The Royal College of Psychiatrists (RCPsych) says withdrawal symptoms normally start soon after a dose is reduced or stopped, sometimes within one or two days or even after a single missed dose, and usually take a few days to build. They’re different for everyone: some people have mild symptoms that pass quickly, while others have more severe symptoms that last much longer, sometimes months or more than a year. A 2019 systematic review (Davies and Read) of 24 studies found withdrawal rates of 27% to 86% (weighted average 56%), and among people with symptoms, 46% rated them at the most severe level offered. The Trintellix label says that although it can be discontinued abruptly, patients stopping 15 or 20 mg a day in trials had transient adverse reactions such as headache and muscle tension, and it includes the class list of serotonergic discontinuation symptoms.

Onset: Within 1 to 2 days of a reduction, stop or missed dose; building over a few days

Headache
Muscle tension
Dizziness
Irritability

Acute withdrawal: First 1 to 2 weeks for many people

Dizziness, ‘brain zaps’ (electric shock sensations)
Anxiety, irritability, mood swings
Vivid dreams, poor sleep
Flu-like feelings, nausea
Headache

Longer withdrawal (some people): Weeks to months, occasionally more than a year

Mood and anxiety symptoms
Dizziness, sensory symptoms
Sleep problems

What makes withdrawal longer or shorter

How long you’ve taken it. RCPsych says people who’ve taken antidepressants for many months or years usually need a slower taper.
Dose and speed of stopping. Abrupt stops are most likely to cause symptoms.
The specific medicine. Shorter-acting antidepressants tend to cause symptoms sooner; fluoxetine leaves the body slowly, so symptoms can start days or weeks later.
Past withdrawal. If you’ve had strong symptoms before, plan a slower taper.

When to see a doctor or get help now

Before stopping or reducing your antidepressant.
Call or text 988 for thoughts of suicide; call 911 if you’re in danger.
Symptoms are severe or not easing. RCPsych says symptoms usually improve quickly (in days or even hours) if the antidepressant is restarted, and a prescriber can then plan a slower taper.
You’re unsure whether it’s withdrawal or your depression or anxiety coming back. RCPsych says withdrawal usually starts within days, while relapse typically takes weeks or months.

Not sure where to start? Call SAMHSA’s free, confidential helpline at 1-800-662-4357, 24/7. See Get Help.

Tapering

The label says it can be stopped abruptly but recommends a gradual reduction whenever possible. We don’t publish dose-by-dose schedules. Your prescriber should set your plan, and adjust it if symptoms appear.

Tips for getting through it

Plan the taper with your prescriber, and tell them about any symptoms, as RCPsych advises
Don’t skip doses, as even one missed dose can cause symptoms
Move your head slowly if zaps are triggered by turning
Tell people close to you so they can support you

Frequently asked questions

Can I stop Trintellix cold turkey?

The label says it can be discontinued abruptly, but recommends tapering whenever possible. Ask your prescriber.

How long does Trintellix withdrawal last?

Trial reports describe transient symptoms; the label doesn’t give a duration.

Why is it different from other SSRIs?

Its long half-life (about 66 hours) means levels fall slowly.

Next steps

Talk to others going through it. Share your experience or ask questions on the Antidepressants & Other Prescriptions board in our community forum. Forum posts are personal experiences, not medical advice. Please read the community guidelines.

Sources

Last reviewed: October 25, 2026. Researched and written by Withdrawal Timelines from the cited sources. This article has not yet been reviewed by a medical professional. See How We Review and our Medical Disclaimer. This is general information, not medical advice.

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